478-45-5
478-45-5 structure
- Name: EMODICACID
- Chemical Name: emodic acid
- CAS Number: 478-45-5
- Molecular Formula: C15H8O7
- Molecular Weight: 300.22000
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2018-03-02 21:46:53
- Modify Date: 2024-01-09 19:25:18
-
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].
| Name | emodic acid |
|---|---|
| Synonyms |
4,5,7-Trihydroxy-9,10-dioxo-9,10-dihydro-anthracen-2-carbonsaeure
Emodinsaeure 1,6,8-trihydroxy-3-carboxylic acid-anthraquinone 4,5,7-Trihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-carboxylic acid 4,5,7-trihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-carboxylic acid 4.5.7-Trioxy-anthrachinon-carbonsaeure-(2) Emodic acid |
| Description | Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Emodic acid(0-100 μM, 72 h)表现出很强的抗增殖活性，在小鼠乳腺癌 4T1、MDA-231 和 MCF-7 细胞系中 IC50 值分别为 9.33、8.56、7.95 μM[1]。 Emodic acid (50 μM, 24 h)在 4T1 细胞系中，可以显著抑制 NF-κB 转录活性 80.75%，抑制 p65 的磷酸化，抑制 MMP-9 mRNA 的表达[1]。 Emodic acid(50 μM, 24 h) 可以抑制促肿瘤细胞因子 IL-1β 和 IL-6 的分泌，以及 VEGF 和 MMP 的表达，进而抑制 4T1 细胞的侵袭和迁移能力[1]。 |
| References |
| Molecular Formula | C15H8O7 |
|---|---|
| Molecular Weight | 300.22000 |
| Exact Mass | 300.02700 |
| PSA | 132.13000 |
| LogP | 1.27700 |