EMODICACID

Modify Date: 2024-01-09 19:25:18

EMODICACID structure	Common Name	EMODICACID
	CAS Number	478-45-5	Molecular Weight	300.22000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₈O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of EMODICACID

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

Name	emodic acid
Synonym	More Synonyms

Description	Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	Emodic acid(0-100 μM, 72 h)表现出很强的抗增殖活性，在小鼠乳腺癌 4T1、MDA-231 和 MCF-7 细胞系中 IC50 值分别为 9.33、8.56、7.95 μM[1]。 Emodic acid (50 μM, 24 h)在 4T1 细胞系中，可以显著抑制 NF-κB 转录活性 80.75%，抑制 p65 的磷酸化，抑制 MMP-9 mRNA 的表达[1]。 Emodic acid(50 μM, 24 h) 可以抑制促肿瘤细胞因子 IL-1β 和 IL-6 的分泌，以及 VEGF 和 MMP 的表达，进而抑制 4T1 细胞的侵袭和迁移能力[1]。
References	[1]. Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853.

Molecular Formula	C₁₅H₈O₇
Molecular Weight	300.22000
Exact Mass	300.02700
PSA	132.13000
LogP	1.27700

4,5,7-Trihydroxy-9,10-dioxo-9,10-dihydro-anthracen-2-carbonsaeure

Emodinsaeure

1,6,8-trihydroxy-3-carboxylic acid-anthraquinone

4,5,7-Trihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-carboxylic acid

4,5,7-trihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-carboxylic acid

4.5.7-Trioxy-anthrachinon-carbonsaeure-(2)

Emodic acid

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: EMODICACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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