Top Suppliers:I want be here
Related CAS#:
19533-92-7 6831-09-0
876724-09-3 364062-05-5
876724-00-4 119725-19-8
143839-02-5 6089-92-5
472-15-1 85999-40-2
1171757-16-6 1170971-74-0
1172763-70-0 1171673-83-8
1171234-65-3 1172748-54-7
1170937-87-7 1170606-04-8
1171747-40-2 1170376-51-8

19533-92-7

19533-92-7 structure
19533-92-7 structure
  • Name: (2α,3β)-2,3-Dihydroxylup-20(29)-en-28-oic acid
  • Chemical Name: 2α,3β-dihydroxy-20(29)-lupen-28-oic acid
  • CAS Number: 19533-92-7
  • Molecular Formula: C30H48O4
  • Molecular Weight: 472.700
  • Catalog: Natural product Moss
  • Create Date: 2016-02-06 12:38:22
  • Modify Date: 2025-08-21 14:40:59
  • Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research[1][2][3].
Name 2α,3β-dihydroxy-20(29)-lupen-28-oic acid
Synonyms Lup-20(29)-en-28-oic acid, 2,3-dihydroxy-, (2α,3β)-
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid
Alphitolic acid
(2α,3β)-2,3-Dihydroxylup-20(29)-en-28-oic acid
Description Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research[1][2][3].
Related Catalog
In Vitro Alphitolic acid (Aophitolic acid) (0-30 µM; 72 hours; HSC-3, SCC2095, and SCC4 cells) has anti-proliferative activity in oral cancer cells in a dose-dependent manner, induces apoptosis and blocks Akt–NF-κB signaling[1]. Alphitolic acid (Aophitolic acid) (0-25 µM; 3-72 hours; SCC4 cells) induces autophagy with increases the expression of autophagosome marker LC3B-II and two autophagyregulatory proteins[1]. Alphitolic acid (Aophitolic acid) (0-25 µM; 72 hours; SCC4 cells) increases p53 phosphorylation and expression, decreases in the expression of the oncogenic E3 ligase MDM2[1]. Alphitolic acid (Aophitolic acid) (0-25 µM; 72 hours; RAW 264.7 macrophages) has anti-inflammatory activity and down-regulates the NO and TNF-α production with IC50 values of 17.6 and 22.7 µM, respectively[2]. Cell Viability Assay[1] Cell Line: HSC-3, SCC2095 and SCC4 cells Concentration: 0, 10, 15, 20, 25 and 30 µM Incubation Time: 72 hours Result: Suppressed the proliferation of SCC4 and SCC2095 cells with IC50 values of 12 and 15 µM, respectively. Apoptosis Analysis[1] Cell Line: SCC4 cells Concentration: 0, 10, 20 and 30 µM Incubation Time: 72 hours Result: Increased the percentage of apoptotic cells from 11.8% to 25.1% in a dose-dependent manner. Western Blot Analysis[1] Cell Line: SCC4 cells Concentration: 0, 10, 15 and 20 µM Incubation Time: 72 hours Result: Decreased the expression of phosphorylation of Akt and its downstream substrates, including p70S6K, S6, and IκBα. Down-regulated the expression of NF-κB and its downstream target gene product Bcl-2. Western Blot Analysis[1] Cell Line: SCC4 cells Concentration: 0, 10, 15, 20 and 25 µM Incubation Time: 3, 6, 12, 24, 48 and 72 hours Result: Increased autophagosome marker LC3B-II in a dose- and time-dependent manner. Increased the expression of autophagy-related protein 7 (Atg7).
In Vivo Alphitolic acid (Aophitolic acid) (47-756 µg/ear; i.h.; adult male CF-1 mice) has anti-inflammatory activity in vivo[3]. Animal Model: Adult male CF-1 mice[3] Dosage: 47, 94, 330, 378 and 756 µg/ear Administration: subcutaneous injection Result: Had anti-inflammatory activity with an ED50 of 0.11 and 0.20 µM in a dose-dependent.
References

[1]. Bai LY, et, al. Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway. 2015 Jan 22; 18(2015):368-378.

[2]. Raju R, et, al. Anti-Inflammatory Chemical Profiling of the Australian Rainforest Tree Alphitonia petriei (Rhamnaceae). Molecules. 2016 Nov 11;21(11):1521.

[3]. Goity LE, et, al. An HPLC-UV and HPLC-ESI-MS based method for identification of antiinflammatory triterpenoids from the extracts of Ugni molinae. 2013 Jan; 12(1):108-116.
Density 1.1±0.1 g/cm3
Boiling Point 566.4±30.0 °C at 760 mmHg
Molecular Formula C30H48O4
Molecular Weight 472.700
Flash Point 310.4±21.1 °C
Exact Mass 472.355255
PSA 77.76000
LogP 7.76
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.546
Hazard Codes Xi
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:19533-92-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 19533-92-7 | Chemsrc address: https://m.chemsrc.com/en/baike/151771.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved