1256264-62-6

1256264-62-6 structure

Name: PF-4950834
Chemical Name: N-methyl-3-[[(4-pyridin-4-ylbenzoyl)amino]methyl]benzamide
CAS Number: 1256264-62-6
Molecular Formula: C₂₁H₁₉N₃O₂
Molecular Weight: 345.39
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2016-02-18 20:55:12
Modify Date: 2024-01-30 19:14:13
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration[1].

Name	N-methyl-3-[[(4-pyridin-4-ylbenzoyl)amino]methyl]benzamide
Synonyms	unii-4a0by63lar PF-4950834

Description	PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Signaling Pathways >> Metabolic Enzyme/Protease >> SGK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Research Areas >> Inflammation/Immunology Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK2:8.35 nM (IC50) ROCK1:33.12 nM (IC50) PKCη:756 nM (IC50) PKA:424 nM (IC50)
In Vitro	PF-4950834 shows inhibition against the AGC (cAMP-dependent protein kinase/protein kinase G/protein kinase C) kinase family with IC50 values of 8.35, 33.12, 102, 216, 321, 384, 411, 424, 457, 578, 736, 756 and 2900 nM for ROCK2, ROCK1, PRKG1, PKN1, SGK2, PRKG2, MSK1, PKA, PRKX, MSK2, P70S6K, PKCη and SGK1, respectively[1].
References	[1]. Rajagopalan LE, et al. Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity. J Pharmacol Exp Ther. 2010 Jun;333(3):707-16.