TH 257
Modify Date: 2024-01-11 13:52:14
TH 257 structure
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Common Name | TH 257 | ||
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| CAS Number | 2244678-29-1 | Molecular Weight | 422.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H26N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TH 257TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1]. |
| Name | TH-257 |
|---|
| Description | TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1]. |
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| Related Catalog | |
| Target |
LIMK1:84 nM (IC50) LIMK2:39 nM (IC50) |
| References |
| Molecular Formula | C24H26N2O3S |
|---|---|
| Molecular Weight | 422.54 |
| Hazard Codes | Xi |
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