1035072-16-2
1035072-16-2 structure
- Name: ML-162
- Chemical Name: 2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
- CAS Number: 1035072-16-2
- Molecular Formula: C23H22CI2N2O3S
- Molecular Weight: 477.403
- Create Date: 2020-01-11 18:56:22
- Modify Date: 2024-01-09 15:20:46
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A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
| Name | 2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide |
|---|---|
| Synonyms |
2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-{2-oxo-2-[(2-phenylethyl)amino]-1-(2-thienyl)ethyl}acetamide
2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide 2-Thiopheneacetamide, α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)- |
| Description | A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells. |
|---|---|
| References | References 1. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. 2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Ras |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 699.3±55.0 °C at 760 mmHg |
| Molecular Formula | C23H22CI2N2O3S |
| Molecular Weight | 477.403 |
| Flash Point | 376.7±31.5 °C |
| Exact Mass | 476.072815 |
| LogP | 4.00 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.630 |