ML-162

Modify Date: 2024-01-09 15:20:46

ML-162 Structure
ML-162 structure
Common Name ML-162
CAS Number 1035072-16-2 Molecular Weight 477.403
Density 1.3±0.1 g/cm3 Boiling Point 699.3±55.0 °C at 760 mmHg
Molecular Formula C23H22CI2N2O3S Melting Point N/A
MSDS N/A Flash Point 376.7±31.5 °C

 Use of ML-162


A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.

 Names

Name 2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
Synonym More Synonyms

 ML-162 Biological Activity

Description A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
References References 1. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. 2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Ras

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 699.3±55.0 °C at 760 mmHg
Molecular Formula C23H22CI2N2O3S
Molecular Weight 477.403
Flash Point 376.7±31.5 °C
Exact Mass 476.072815
LogP 4.00
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.630

 Synonyms

2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-{2-oxo-2-[(2-phenylethyl)amino]-1-(2-thienyl)ethyl}acetamide
2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
2-Thiopheneacetamide, α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-
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