339304-10-8
339304-10-8 structure
- Name: VPC-18005
- Chemical Name: {2-[(2E)-2-(4-Isopropylbenzylidene)hydrazino]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetic acid
- CAS Number: 339304-10-8
- Molecular Formula: C15H17N3O3S
- Molecular Weight: 319.379
- Create Date: 2020-01-11 15:54:57
- Modify Date: 2025-09-11 13:03:18
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VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM); markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.
| Name | {2-[(2E)-2-(4-Isopropylbenzylidene)hydrazino]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetic acid |
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| Synonyms |
{2-[(2E)-2-(4-Isopropylbenzylidene)hydrazino]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetic acid
2-(2-{(Z)-2-[(E)-(4-isopropylphenyl)methylidene]hydrazono}-4-oxo-1,3-thiazolan-5-yl)acetic acid 5-Thiazoleacetic acid, 4,5-dihydro-2-[(2E)-2-[[4-(1-methylethyl)phenyl]methylene]hydrazinyl]-4-oxo- MFCD00758307 MFCD28248832 |
| Description | VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM); markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model. |
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| References | References 1. Butler MS, et al. Oncotarget. 2017 Jun 27;8(26):42438-42454. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 506.3±52.0 °C at 760 mmHg |
| Molecular Formula | C15H17N3O3S |
| Molecular Weight | 319.379 |
| Flash Point | 260.0±30.7 °C |
| Exact Mass | 319.099060 |
| LogP | 2.72 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.647 |