1621375-32-3
1621375-32-3 structure
- Name: VPC 14449
- Chemical Name: 4-[4-(4,5-Dibromo-1H-imidazol-1-yl)-1,3-thiazol-2-yl]morpholine
- CAS Number: 1621375-32-3
- Molecular Formula: C10H10Br2N4OS
- Molecular Weight: 394.086
- Create Date: 2020-01-11 11:09:58
- Modify Date: 2024-01-11 22:53:15
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VPC 14449 is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM, without affecting AR protein expression; effectively blocks transcriptional activity of full-length and splice variant AR forms at low to sub-micromolar concentrations; reduces tumor volume and abolishes PSA production in LNCaP xenograft model.
| Name | 4-[4-(4,5-Dibromo-1H-imidazol-1-yl)-1,3-thiazol-2-yl]morpholine |
|---|---|
| Synonyms |
MFCD29477380
Morpholine, 4-[4-(4,5-dibromo-1H-imidazol-1-yl)-2-thiazolyl]- 4-[4-(4,5-Dibromo-1H-imidazol-1-yl)-1,3-thiazol-2-yl]morpholine |
| Description | VPC 14449 is a potent and selective androgen receptor DNA-binding domain (AR-DBD) inhibitor with IC50 of 0.34 uM, without affecting AR protein expression; effectively blocks transcriptional activity of full-length and splice variant AR forms at low to sub-micromolar concentrations; reduces tumor volume and abolishes PSA production in LNCaP xenograft model. |
|---|---|
| References | References 1. Dalal K, et al. Mol Cancer Ther. 2017 Aug 3. pii: molcanther.0259.2017. 2. Dalal K, et al. J Biol Chem. 2014 Sep 19;289(38):26417-29. View Related Products by Target Androgen Receptor (AR) |
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 542.8±60.0 °C at 760 mmHg |
| Molecular Formula | C10H10Br2N4OS |
| Molecular Weight | 394.086 |
| Flash Point | 282.1±32.9 °C |
| Exact Mass | 391.894196 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.802 |