VPC-18005

Modify Date: 2024-06-21 02:34:35

VPC-18005 structure	Common Name	VPC-18005
	CAS Number	339304-10-8	Molecular Weight	319.379
	Density	1.4±0.1 g/cm3	Boiling Point	506.3±52.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₇N₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	260.0±30.7 °C

Use of VPC-18005

VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM); markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.

Name	{2-[(2E)-2-(4-Isopropylbenzylidene)hydrazino]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetic acid
Synonym	More Synonyms

Description	VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM); markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.
References	References 1. Butler MS, et al. Oncotarget. 2017 Jun 27;8(26):42438-42454. View Related Products by Target Other Targets

Density	1.4±0.1 g/cm3
Boiling Point	506.3±52.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₇N₃O₃S
Molecular Weight	319.379
Flash Point	260.0±30.7 °C
Exact Mass	319.099060
LogP	2.72
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.647