1030769-75-5
1030769-75-5 structure
- Name: SRI 37892
- Chemical Name: SRI 37892
- CAS Number: 1030769-75-5
- Molecular Formula: C26H19N5O2S
- Molecular Weight: 465.531
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 22:42:50
- Modify Date: 2024-04-07 12:42:27
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SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay; also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM, demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively; targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling.
| Name | SRI 37892 |
|---|
| Description | SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay; also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM, demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively; targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling. |
|---|---|
| References | References 1. Zhang W, et al. Oncotarget. 2017 Sep 6;8(53):91459-91470. View Related Products by Target Frizzled |
| Molecular Formula | C26H19N5O2S |
|---|---|
| Molecular Weight | 465.531 |