1208824-23-0
1208824-23-0 structure
- Name: SRI-41897
- Chemical Name: SRI-41897
- CAS Number: 1208824-23-0
- Molecular Formula: C13H11F2N3O2
- Molecular Weight: 279.247
- Create Date: 2022-07-11 17:11:01
- Modify Date: 2024-08-10 05:22:00
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SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs).
| Name | SRI-41897 |
|---|
| Description | SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs). |
|---|---|
| References | 1. Carolyn A Robinson, et al. Viruses. 2022 Apr 15;14(4):817. |
| Molecular Formula | C13H11F2N3O2 |
|---|---|
| Molecular Weight | 279.247 |