2071636-15-0
2071636-15-0 structure
- Name: Lp-PLA2-IN-2
- Chemical Name: Lp-PLA2-IN-2
- CAS Number: 2071636-15-0
- Molecular Formula: C19H23FN2O4S
- Molecular Weight: 394.46
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2020-01-23 22:41:51
- Modify Date: 2024-01-10 17:14:03
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Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1].
| Name | Lp-PLA2-IN-2 |
|---|
| Description | Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1]. |
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| Related Catalog | |
| Target |
Lp-PLA2:120 nM (IC50) |
| In Vitro | Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with an IC50 of 62 nM in PED6 assay[1]. |
| In Vivo | Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively[1]. Animal Model: Male Han Wistar rats (250-300 g)[1] Dosage: 1 mg/kg Administration: i.v. (Pharmacokinetic Analysis) Result: The Cl, Vss and t1/2 values were 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively. |
| References |
| Molecular Formula | C19H23FN2O4S |
|---|---|
| Molecular Weight | 394.46 |
| Hazard Codes | Xi |
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