Lp-PLA2-IN-2

Modify Date: 2024-01-10 17:14:03

Lp-PLA2-IN-2 structure	Common Name	Lp-PLA2-IN-2
	CAS Number	2071636-15-0	Molecular Weight	394.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₃FN₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lp-PLA2-IN-2

Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1].

Name	Lp-PLA2-IN-2

Description	Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology
Target	Lp-PLA2:120 nM (IC50)
In Vitro	Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with an IC50 of 62 nM in PED6 assay[1].
In Vivo	Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively[1]. Animal Model: Male Han Wistar rats (250-300 g)[1] Dosage: 1 mg/kg Administration: i.v. (Pharmacokinetic Analysis) Result: The Cl, Vss and t1/2 values were 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively.
References	[1]. Woolford AJ, et al. Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J Med Chem. 2016 Dec 8;59(23):10738-10749.

Molecular Formula	C₁₉H₂₃FN₂O₄S
Molecular Weight	394.46

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: Lp-PLA2-IN-2
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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