![]() CGP 78608 hydrochloride structure
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Common Name | CGP 78608 hydrochloride | ||
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CAS Number | 1135278-54-4 | Molecular Weight | 414.58 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C11H14BrClN3O5P | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of CGP 78608 hydrochlorideCGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2]. |
Name | CGP 78608 hydrochloride |
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Description | CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity[1][2]. |
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Related Catalog | |
In Vitro | CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites[2]. CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity[3]. |
In Vivo | CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1]. |
References |
[1]. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. |
Molecular Formula | C11H14BrClN3O5P |
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Molecular Weight | 414.58 |