SRI-41897
Modify Date: 2025-09-02 20:02:29
SRI-41897 structure
|
Common Name | SRI-41897 | ||
|---|---|---|---|---|
| CAS Number | 1208824-23-0 | Molecular Weight | 279.247 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H11F2N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRI-41897SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs). |
| Name | SRI-41897 |
|---|
| Description | SRI-41897 is a specific small molecule inhibitor of HIV-1 N-terminal region of NL4-3 Vpu (HIV-1 NL4-3 Vpu) with EC50 of 4.4 uM in the GaLV inhibition assays.SRI-41897 blocks Vpu-mediated modulation of CD4, BST-2/Tetherin and antibody dependent cell-mediated toxicity (ADCC).SRI-41897 rescues CD4 surface expression by 47% on infected TZM-GFP cells, also rescues the expression of CD4 and Tetherin in human peripheral blood mononuclear cells (PBMCs). |
|---|---|
| References | 1. Carolyn A Robinson, et al. Viruses. 2022 Apr 15;14(4):817. |
| Molecular Formula | C13H11F2N3O2 |
|---|---|
| Molecular Weight | 279.247 |
| InChIKey | RPWNPRWJNGJESZ-UHFFFAOYSA-N |
| SMILES | CN(Cc1ccc(F)cc1F)c1ccc([N+](=O)[O-])cn1 |