HDAC6-IN-5
Modify Date: 2025-09-05 19:00:16
HDAC6-IN-5 structure
|
Common Name | HDAC6-IN-5 | ||
|---|---|---|---|---|
| CAS Number | 2413603-15-1 | Molecular Weight | 408.25 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H14BrN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC6-IN-5HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1]. |
| Name | HDAC6-IN-5 |
|---|
| Description | HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC6:0.026 ± 0. μM (IC50) HDAC1:0.09 ± 0.0 μM (IC50) HDAC:0.16 ± 0.0 μM (IC50) HDAC3:0.33 ± 0. μM (IC50) HDAC2:0.48 ± 0.0 μM (IC50) HDAC9:5.51 ± 0.0 μM (IC50) HDAC5:7.19 ± 0.4 μM (IC50) HDAC4:7.85 ± 0.6 μM (IC50) HDAC7:9.13 ± 0.3 μM (IC50) |
| In Vitro | HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively[1] |
| References |
| Molecular Formula | C20H14BrN3O2 |
|---|---|
| Molecular Weight | 408.25 |