2417995-10-7
2417995-10-7 structure
- Name: COX-2-IN-24
- Chemical Name: COX-2-IN-24
- CAS Number: 2417995-10-7
- Molecular Formula: C24H24BrN5O3S2
- Molecular Weight: 574.51
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2022-09-04 16:25:48
- Modify Date: 2024-07-08 23:31:32
-
COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
| Name | COX-2-IN-24 |
|---|
| Description | COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities. |
|---|---|
| Related Catalog | |
| Target |
COX-2:0.17 μM (IC50) |
| In Vivo | COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model[1]. COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model [1]. Animal Model: Mature male albino rats[1] Dosage: 9mg/100g Administration: Intraperitoneal injection; 9mg/100g; once an hour; 4 hours Result: Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model. Animal Model: Mature male albino rats[1] Dosage: 9mg/100g Administration: Oral gavage; 9mg/100g; once a day; 3 days Result: Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model. |
| References |
| Molecular Formula | C24H24BrN5O3S2 |
|---|---|
| Molecular Weight | 574.51 |