2417995-10-7

2417995-10-7 structure

2417995-10-7 structure

Name: COX-2-IN-24
Chemical Name: COX-2-IN-24
CAS Number: 2417995-10-7
Molecular Formula: C₂₄H₂₄BrN₅O₃S₂
Molecular Weight: 574.51
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-09-04 16:25:48
Modify Date: 2024-07-08 23:31:32
COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

Name	COX-2-IN-24

Description	COX-2-IN-24 is an orally active inhibitor of COX-2 with IC50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.
Related Catalog	Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2:0.17 μM (IC50)
In Vivo	COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model[1]. COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model [1]. Animal Model: Mature male albino rats[1] Dosage: 9mg/100g Administration: Intraperitoneal injection; 9mg/100g; once an hour; 4 hours Result: Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model. Animal Model: Mature male albino rats[1] Dosage: 9mg/100g Administration: Oral gavage; 9mg/100g; once a day; 3 days Result: Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model.
References	[1]. Tarek S Ibrahim, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878.

Molecular Formula	C₂₄H₂₄BrN₅O₃S₂
Molecular Weight	574.51