2409793-28-6
2409793-28-6 structure
- Name: PROTAC EGFR degrader 6
- Chemical Name: PROTAC EGFR degrader 6
- CAS Number: 2409793-28-6
- Molecular Formula: C49H57FN12O5
- Molecular Weight: 913.05
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-17 09:57:34
- Modify Date: 2024-01-07 19:12:34
-
PROTAC EGFR degrader 6 (Compound 2), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].
| Name | PROTAC EGFR degrader 6 |
|---|
| Description | PROTAC EGFR degrader 6 (Compound 2), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 180 nM (EGFRDel19 in HCC827 cells)[1] DC50: 45.2 nM (EGFRDel19 in HCC827 cells)[1] |
| In Vitro | PROTAC EGFR degrader 6 (compound 2) (0.001-10 μM; 48 hours) exhibits potent EGFR degradation activity with certain concentration-dependent manner; and shows DC50 of 45.2 nM in HCC827 cells[1]. PROTAC EGFR degrader 6 (100 nM; 4-96 hours) degradates EGFR protein in a time-dependent manner, and reaches the maximum degradation rate (Dmax = 87%) at 96 h[1]. PROTAC EGFR degrader 6 (0.1, 1 and 10 μM; 48 hours) shows weak degradation activity on EGFR in H1975 and A549 cells[1]. PROTAC EGFR degrader 6 (0.1 and 1 μM; 32 hours) induce HCC827 apoptosis, and the percentages of apoptosis cells are 53.72% and 32.31% at 0.1 and 1 μM, respectively[1]. |
| References |
| Molecular Formula | C49H57FN12O5 |
|---|---|
| Molecular Weight | 913.05 |