PROTAC EGFR degrader 6
Modify Date: 2024-01-07 19:12:34
PROTAC EGFR degrader 6 structure
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Common Name | PROTAC EGFR degrader 6 | ||
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| CAS Number | 2409793-28-6 | Molecular Weight | 913.05 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H57FN12O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC EGFR degrader 6PROTAC EGFR degrader 6 (Compound 2), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1]. |
| Name | PROTAC EGFR degrader 6 |
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| Description | PROTAC EGFR degrader 6 (Compound 2), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1]. |
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| Related Catalog | |
| Target |
IC50: 180 nM (EGFRDel19 in HCC827 cells)[1] DC50: 45.2 nM (EGFRDel19 in HCC827 cells)[1] |
| In Vitro | PROTAC EGFR degrader 6 (compound 2) (0.001-10 μM; 48 hours) exhibits potent EGFR degradation activity with certain concentration-dependent manner; and shows DC50 of 45.2 nM in HCC827 cells[1]. PROTAC EGFR degrader 6 (100 nM; 4-96 hours) degradates EGFR protein in a time-dependent manner, and reaches the maximum degradation rate (Dmax = 87%) at 96 h[1]. PROTAC EGFR degrader 6 (0.1, 1 and 10 μM; 48 hours) shows weak degradation activity on EGFR in H1975 and A549 cells[1]. PROTAC EGFR degrader 6 (0.1 and 1 μM; 32 hours) induce HCC827 apoptosis, and the percentages of apoptosis cells are 53.72% and 32.31% at 0.1 and 1 μM, respectively[1]. |
| References |
| Molecular Formula | C49H57FN12O5 |
|---|---|
| Molecular Weight | 913.05 |