792898-18-1
792898-18-1 structure
- Name: JNJ-1289
- Chemical Name: JNJ-1289
- CAS Number: 792898-18-1
- Molecular Formula: C16H12N4OS
- Molecular Weight: 308.36
- Catalog: Research Areas Cancer
- Create Date: 2022-09-25 11:36:10
- Modify Date: 2024-09-30 11:30:21
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JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1].
| Name | JNJ-1289 |
|---|
| Description | JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1]. |
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| Related Catalog | |
| Target |
IC50: 50 nM (hSMOX)[1]; >2 μM (hPAOX and LSD1)[1]. |
| In Vitro | JNJ-1289 (0 and 2 h) inhibits hSMOX activity in a time-dependent manner[1]. JNJ-1289 initially forms a weak complex with hSMOX with an apparent Ki value of 1.4 μM, followed by a relatively slow protein isomerization that forms the final tightly bound inhibitor-enzyme complex[1]. |
| References |
| Molecular Formula | C16H12N4OS |
|---|---|
| Molecular Weight | 308.36 |