2225940-96-3
2225940-96-3 structure
- Name: TSR-033
- Chemical Name: TSR-033
- CAS Number: 2225940-96-3
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-01-19 14:01:59
- Modify Date: 2023-01-19 14:01:59
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TSR-033 is a high affinity human IgG4 antibody targeting LAG-3 (lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed with PD-1, that enhances T cell function and PD-1 blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity[1].
| Name | TSR-033 |
|---|
| Description | TSR-033 is a high affinity human IgG4 antibody targeting LAG-3 (lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed with PD-1, that enhances T cell function and PD-1 blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity[1]. |
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| Related Catalog | |
| In Vitro | TSR-033 (0.01-1000 nmol/L, 48 h) 可以增加原代人类 CD4 T细胞和树突状细胞的 IL2 产生，并增强T细胞效应器功能[1]。 |
| In Vivo | TSR-033 (i.p.,10 mg/kg, twice weekly, 40 days) 在 A549 HuNOG-EXL NSCLC 小鼠肿瘤模型中，对肿瘤生长有中等程度的抑制作用，单独治疗终止时TGI 为 23%，而与 TSR-042 联合治疗有累积效应，能更大程度地阻碍肿瘤生长，终止时 TGI 为 45%[1]。 |
| References |
| No Any Chemical & Physical Properties |