Pyridoxine hydrochloride

Modify Date: 2024-01-02 11:15:15

Pyridoxine hydrochloride structure	Common Name	Pyridoxine hydrochloride
	CAS Number	58-56-0	Molecular Weight	205.639
	Density	N/A	Boiling Point	491.9ºC at 760 mmHg
	Molecular Formula	C₈H₁₂ClNO₃	Melting Point	214-215 °C(lit.)
	MSDS	Chinese USA	Flash Point	251.3ºC
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of Pyridoxine hydrochloride

Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

Name	pyridoxine hydrochloride
Synonym	More Synonyms

Description	Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Neurological Disease Natural Products >> Others
Target	Nrf2[1]
In Vitro	Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References	[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

Boiling Point	491.9ºC at 760 mmHg
Melting Point	214-215 °C(lit.)
Molecular Formula	C₈H₁₂ClNO₃
Molecular Weight	205.639
Flash Point	251.3ºC
Exact Mass	205.050568
PSA	73.58000
LogP	0.88220
Storage condition	2-8°C
Stability	Stable. Protect from air and light.
Water Solubility	0.1 g/mL (20 ºC)

Pyridoxine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1350000

CHEMICAL NAME :: Pyridoxol, hydrochloride

CAS REGISTRY NUMBER :: 58-56-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C8-H11-N-O3.Cl-H

MOLECULAR WEIGHT :: 205.66

WISWESSER LINE NOTATION :: T6NJ B1 CQ D1Q E1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21400 mg/kg/15W-I

TOXIC EFFECTS :: Spinal Cord - demyelination Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 mg/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 2 mg/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8040 ug/kg

SEX/DURATION :: female 14 week(s) pre-mating - 12 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 gm/kg

SEX/DURATION :: male 2 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 7500 mg/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 gm/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753 (estimated)

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UV1350000
HS Code	2936250000

Precursor 9
CAS#:10030-93-0 TRI-ACETYL PYRI... CAS#:524-36-7 Pyridoxamine di... CAS#:4469-34-5 1,3-Dioxepin,4,... CAS#:24201-52-3 5-butoxy-4-meth...
CAS#:108-31-6 Maleic anhydride CAS#:5417-35-6 4,7-dihydro-2-i... CAS#:10500-75-1 (5-ethoxy-oxazo... CAS#:5417-32-3 4,7-Dihydro-1,3...
CAS#:541-59-3 Maleimide
DownStream 10
CAS#:529-96-4 pyridoxamine ph... CAS#:94-75-7 2,4-Dichlorophe... CAS#:447-05-2 pyridoxine 5'-p... CAS#:948-00-5 3,3,8-trimethyl...
CAS#:77-76-9 2,2-Dimethoxypropane CAS#:65-23-6 Pyridoxine CAS#:524-36-7 Pyridoxamine di... CAS#:54-47-7 Pyridoxal phosphate
CAS#:66-72-8 pyridoxal CAS#:10030-93-0 TRI-ACETYL PYRI...

HS Code	2936250000
Summary	HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%

Protein enrichment of an Opuntia ficus-indica cladode hydrolysate by cultivation of Candida utilis and Kluyveromyces marxianus.

J. Sci. Food Agric. 95(5) , 1094-102, (2015)

The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated pr...

Validated stability-indicating liquid chromatographic method for the determination of ribavirin in the presence of its degradation products: application to degradation kinetics.

J. Chromatogr. Sci. 53 , 603-11, (2015)

Ribavirin was found to be liable to acidic, alkaline, oxidative and photolytic degradation. Hence, a simple, sensitive and stability-indicating reversed-phase liquid chromatographic method was develop...

Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.

Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014)

We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season...

vitamin B6 hydrochloride

Hexobion

5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride

3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)

Pyridox

Hexavibex

aderoxin

aderoxine

hexermin

adermine hydrochloride

Pyridoxinium chloride

Bonasanit

Pyridoxine, hydrochloride

PYRIDOXINE HCL

Pyridoxine hydrogen chloride

pyridoxol hydrochloride

Benadon

MFCD08064207

paxadon

T6NJ B1 CQ D1Q E1Q &&HCl

Hexabetalin

pyridoxine monohydrochloride

EINECS 200-386-2

4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride (1:1)

Pyridoxol HCl

becilan

3-Hydroxy-4,5-dimethylol-α-picoline hydrochloride

Pyridoxine hydrochloride

4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride (1:1)

5-hydroxy--6-methyl-3,4-pyridine dimethanol hydrochloride

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pyridoxine hydrochloride
Price: ￥178.0/100g ￥608.0/500g ￥78.0/25g ￥108.0/20mg
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Pyridoxine hydrochloride
Price: $50.0/100mg $100.0/250mg $200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pyridoxine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Pyridoxine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: pyridoxine hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Pyridoxine hydrochloride suppliers

Price: ￥550/10 mM * 1 mL in DMSO

Reference only. check more Pyridoxine hydrochloride price

Pyridoxine hydrochloride

Use of Pyridoxine hydrochloride

Names