Pyridoxine hydrochloride

Modify Date: 2026-07-01 11:09:46

Pyridoxine hydrochloride structure	Common Name	Pyridoxine hydrochloride
	CAS Number	58-56-0	Molecular Weight	205.639
	Density	N/A	Boiling Point	491.9ºC at 760 mmHg
	Molecular Formula	C₈H₁₂ClNO₃	Melting Point	214-215 °C(lit.)
	MSDS	Chinese USA	Flash Point	251.3ºC
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of Pyridoxine hydrochloride

Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	pyridoxine hydrochloride
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Neurological Disease Natural Products >> Others
Target	Nrf2[1]
In Vitro	Pyridoxine exerts a protective potential against AD, attenuates ROS levels, decreases the expressions of cytoplasmic Nrf2, and upregulates whole-cell HO-1 expression[1].
References	[1]. Li C, et al. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):119-124.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Boiling Point	491.9ºC at 760 mmHg
Melting Point	214-215 °C(lit.)
Molecular Formula	C₈H₁₂ClNO₃
Molecular Weight	205.639
Flash Point	251.3ºC
Exact Mass	205.050568
PSA	73.58000
LogP	0.88220
Storage condition	2-8°C
Stability	Stable. Protect from air and light.
Water Solubility	0.1 g/mL (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Pyridoxine hydrochloride MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1350000

CHEMICAL NAME :: Pyridoxol, hydrochloride

CAS REGISTRY NUMBER :: 58-56-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C8-H11-N-O3.Cl-H

MOLECULAR WEIGHT :: 205.66

WISWESSER LINE NOTATION :: T6NJ B1 CQ D1Q E1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 660 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21400 mg/kg/15W-I

TOXIC EFFECTS :: Spinal Cord - demyelination Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 mg/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 2 mg/kg

SEX/DURATION :: female 38 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8040 ug/kg

SEX/DURATION :: female 14 week(s) pre-mating - 12 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 gm/kg

SEX/DURATION :: male 2 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 7500 mg/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 gm/kg

SEX/DURATION :: male 6 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UV1350000
HS Code	2936250000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:10030-93-0 TRI-ACETYL PYRI... CAS#:524-36-7 Pyridoxamine di... CAS#:4469-34-5 1,3-Dioxepin,4,... CAS#:24201-52-3 5-butoxy-4-meth...
CAS#:108-31-6 Maleic anhydride CAS#:5417-35-6 4,7-dihydro-2-i... CAS#:10500-75-1 (5-ethoxy-oxazo... CAS#:5417-32-3 4,7-Dihydro-1,3...
CAS#:541-59-3 Maleimide
DownStream 10
CAS#:529-96-4 pyridoxamine ph... CAS#:94-75-7 2,4-Dichlorophe... CAS#:447-05-2 pyridoxine 5'-p... CAS#:948-00-5 3,3,8-trimethyl...
CAS#:77-76-9 2,2-Dimethoxypropane CAS#:65-23-6 Pyridoxine CAS#:524-36-7 Pyridoxamine di... CAS#:54-47-7 Pyridoxal phosphate
CAS#:66-72-8 pyridoxal CAS#:10030-93-0 TRI-ACETYL PYRI...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2936250000
Summary	HS: 2936250000. (5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:4.0%. general tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Protein enrichment of an Opuntia ficus-indica cladode hydrolysate by cultivation of Candida utilis and Kluyveromyces marxianus.

J. Sci. Food Agric. 95(5) , 1094-102, (2015)

The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated pr...

Validated stability-indicating liquid chromatographic method for the determination of ribavirin in the presence of its degradation products: application to degradation kinetics.

J. Chromatogr. Sci. 53 , 603-11, (2015)

Ribavirin was found to be liable to acidic, alkaline, oxidative and photolytic degradation. Hence, a simple, sensitive and stability-indicating reversed-phase liquid chromatographic method was develop...

Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.

Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014)

We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

vitamin B6 hydrochloride

Hexobion

5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride

3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)

Pyridox

Hexavibex

aderoxin

aderoxine

hexermin

adermine hydrochloride

Pyridoxinium chloride

Bonasanit

Pyridoxine, hydrochloride

PYRIDOXINE HCL

Pyridoxine hydrogen chloride

pyridoxol hydrochloride

Benadon

MFCD08064207

paxadon

T6NJ B1 CQ D1Q E1Q &&HCl

Hexabetalin

pyridoxine monohydrochloride

EINECS 200-386-2

4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride (1:1)

Pyridoxol HCl

becilan

3-Hydroxy-4,5-dimethylol-α-picoline hydrochloride

Pyridoxine hydrochloride

4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride (1:1)

5-hydroxy--6-methyl-3,4-pyridine dimethanol hydrochloride

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of pyridoxine hydrochloride?

A: LogP of pyridoxine hydrochloride is 0.88220.

Q: What are the storage conditions for pyridoxine hydrochloride?

A: Storage conditions for pyridoxine hydrochloride: 2-8°C.

Q: What are the upstream materials of pyridoxine hydrochloride?

A: Related upstream materials(CAS) of pyridoxine hydrochloride: 10030-93-0;524-36-7;4469-34-5;24201-52-3;108-31-6;5417-35-6;10500-75-1;5417-32-3;541-59-3.

Q: What is the polar surface area (PSA) of pyridoxine hydrochloride?

A: Polar surface area (PSA) of pyridoxine hydrochloride is 73.58000.

Q: What are the uses of pyridoxine hydrochloride?

A: Main uses of pyridoxine hydrochloride: Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.

Q: How is the water solubility of pyridoxine hydrochloride?

A: Water solubility of pyridoxine hydrochloride: 0.1 g/mL (20 ºC).

Q: What is the molecular weight of pyridoxine hydrochloride?

A: Molecular weight of pyridoxine hydrochloride is 205.639.

Q: What are the downstream products of pyridoxine hydrochloride?

A: Related downstream products(CAS) of pyridoxine hydrochloride: 529-96-4;94-75-7;447-05-2;948-00-5;77-76-9;65-23-6;524-36-7;54-47-7;66-72-8;10030-93-0.

Q: What is the molecular formula of pyridoxine hydrochloride?

A: Molecular formula of pyridoxine hydrochloride is C8H12ClNO3.

Q: What is the English name of pyridoxine hydrochloride?

A: The English name of pyridoxine hydrochloride is pyridoxine hydrochloride.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pyridoxine hydrochloride
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Pyridoxine hydrochloride
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pyridoxine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: pyridoxine hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Pyridoxine hydrochloride suppliers

Price: ￥550/10 mM * 1 mL in DMSO

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