131-18-0

131-18-0 structure

Name: Di-n-Amyl phthalate
Chemical Name: dipentyl phthalate
CAS Number: 131-18-0
Molecular Formula: C₁₈H₂₆O₄
Molecular Weight: 306.40
Catalog: Chemical reagent Organic reagent Ester Amyl ester compound
Create Date: 2018-04-26 08:00:00
Modify Date: 2026-07-02 22:05:17
Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].

Name	dipentyl phthalate
Synonyms	PHTHALIC ACID DIAMYL ESTER DIPENTYL PHTHALATE dipentyl benzene-1,2-dicarboxylate Di-n-amyl-o-phthalate DIPENTYLPHTHALATE, 1000MG,NEAT DI-N-PENTYL PHTHALATE Dipentyl benzene-1,2-dicboxylate PHTHALIC ACID BIS-PENTYL ESTER DIPENTYLPHTHALATEESTER DAP/Dipentyl phthalate DI-N-PHTHALATE 1,2-Benzenedicarboxylic acid dipentyl ester di-n-pentyl phthalate Di-N-Pentyl Phthalate (100μg/mL) DI-N-PENTYL PHTHALATE-3,4,5,6-D4 DiaMyl Phthalate Phthalic acid. bis-n-pentyl ester in Cyclohexane PHTHALIC ACID, BIS-N-PENTYL ESTER amylphthalate DI-N-AMYL PHTHALATE Diamyl phthalate@100 μg/mL in MeOH MFCD01861607 Di-n-pentyl phthalate in isooctane Dipentyl phthalate, R 1,2-dipentyl benzene-1,2-dicboxylate DIAMYL PHTHALATE Di-n-pentyl-phthalate di-1-pentylphthalate Dipentyl Phthalate Standd phthalic acid di-n-pentyl ester Diamyl phthalate,100 μL/mL in MeOH Phthalic acid. bis-n-pentyl ester in Methanol Diamyl phthalate [-0] Dipentyl phthalate C16175500 PhthaliCacid, bis-n-pentyLester 1,2-Benzenedicarboxylic acid, 1,2-dipentyl ester Amoil Phthalic acid, bis-n-pentyl ester 100 μg/mL in Acetonitrile ai3-00363(usda) 1,2-Benzenedicarboxylic acid, dipentyl ester EINECS 205-017-9 Phthalate Mixture 392 μg/mL in Methanol 1,2-Benzenedicboxylicacid,dipentylester 1,2-Benzenedicboxylic acid, 1,2-dipentyl ester PHTHALIC ACID, BIS-AMYL ESTER Diamyl phthalate 500mg [-0] UNII-5DC92K224X PHTHALIC ACID DIPENTYL ESTER Dipentyl Phthalate Phthalic Acid Diamyl Ester Phthalic Acid Dipentyl Ester Di-n-pentyl phthalate-13C6 (phenyl-13C6) in n-nonane DIAMYLPHTHALATE Dipentylphthalate dipentyl ester phthalic acid 3-(4-(((tert-butoxycbonyl)amino)methyl)phenyl)-2,2-dimethylpropanoic acid DI-N-PENTYL PHTHALATE-D4 phthalic acid dipentyl ester Amyl phthalate DIPENTYL 1,2-BENZENEDICBOXYLATE PHTHALIC ACID DI-N-AMYL ESTER GB/-2016 Phthalates Mixture 572 10 μg/mL in Hexane Phthalic acid diamyl ester Phthalic acid, pentyl 2-pentyl ester Dipentyl phthalate (DNPP) Solution, 100ppm ipentylphthalate Dipentyl phthalate (DNPP) Phthalic acid di-n-pentyl ester DiamylPhthalate>

Description	Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
References	[1]. Haiqiong Chen,et al. Exposure to dipentyl phthalate in utero disrupts the adrenalcortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPKphosphorylation. Environ Toxicol. 2023 May;38(5):997-1010. [2]. Bethany R Hannas,et al. Dipentyl phthalate dosing during sexual differentiation disruptsfetal testis function and postnatal development of the male Sprague-Dawley ratwith greater relative potency than other phthalates. Toxicol Sci. 2011Mar;120(1):184-93.

Density	1.0±0.1 g/cm3
Boiling Point	357.0±10.0 °C at 760 mmHg
Melting Point	-55ºC
Molecular Formula	C₁₈H₂₆O₄
Molecular Weight	306.40
Flash Point	188.8±8.5 °C
Exact Mass	306.183105
PSA	52.60000
LogP	5.89
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.496

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI1930000

CHEMICAL NAME :: Phthalic acid, dipentyl ester

CAS REGISTRY NUMBER :: 131-18-0

BEILSTEIN REFERENCE NO. :: 1987323

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H26-O4

MOLECULAR WEIGHT :: 306.44

WISWESSER LINE NOTATION :: 5OVR BVO5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6600 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 63,120,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2206 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 15,265,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,528,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 316 gm/kg

SEX/DURATION :: male 15 week(s) pre-mating female 15 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 12,508,1989 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989

Symbol	GHS08, GHS09
Signal Word	Danger
Hazard Statements	H360-H400
Precautionary Statements	P201-P273-P308 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R60
Safety Phrases	S45;S53;S61
RIDADR	UN 3082 9/PG 3
WGK Germany	3
RTECS	TI1930000
Packaging Group	III
HS Code	2917349000

85-44-9

71-41-0

~93%

131-18-0

Literature: Zhang, Gui-Sheng Synthetic Communications, 1999 , vol. 29, # 4 p. 607 - 611

71-41-0

88-99-3

131-18-0

Literature: US2130014 , ;

Precursor 3
85-44-9 71-41-0 88-99-3
DownStream 2
85-44-9 109-68-2

HS Code	2917349000
Summary	2917349000 other esters of orthophthalic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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