64-77-7
64-77-7 structure
- Name: Tolbutamide
- Chemical Name: tolbutamide
- CAS Number: 64-77-7
- Molecular Formula: C12H18N2O3S
- Molecular Weight: 270.348
- Catalog: API Hormone and endocrine-regulating drugs Pancreatic hormones and other blood sugar regulating drugs
- Create Date: 2018-02-05 08:00:00
- Modify Date: 2026-07-01 16:56:59
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Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.Target: Potassium ChannelTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Tolbutamide act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Tolbutamide belongs to a class of medications called sulfonylureas. Tolbutamide inhibits both the basal and the cyclic AMP-stimulated protein kinase activities and the IC50 of Tolbutamide is 4 mM. Similar Tolbutamide concentrations are required for half maximal inhibition of in vitro lipolysis induced by hormones (norepinephrine and ACTH) or by dibutyryl cyclic AMP plus theophylline. Tolbutamide also inhibits both soluble and membrane-bound protein kinase from canine heart. The Tolbutamide inhibition of adipose tissue cyclic AMP-dependent protein kinase is one possible explanation for the antilipolytic effects of this drug [1]. Tolbutamide inhibits C6-glioma cell proliferation by increasing Cx43, which correlates with a reduction in pRb phosphorylation due to the up-regulation of the Cdk inhibitors p21 and p27 [2].
| Name | tolbutamide |
|---|---|
| Synonyms |
(p-tolyl-4-sulfonyl)-1-butylurea
Orinase Anti-Kir5.1, C-Terminal antibody produced in rabbit N-Butyl-N'-p-toluenesulfonylurea Diabetol Anti-KCNK1, C-Terminal antibody produced in rabbit n-butyl-n’-toluene-p-sulfonylurea Diabetamid N-Butyl-N'-(p-tolylsulfonyl)urea Sulfur & SeleniuM CoMpounds Mobenol Rastinon d860 [3H]-Tolbutamide subfamily K InterMediates & Fine CheMicals BZ 55 Tolbutamide Solution, 100ppm Diabuton N-(Butylcarbamoyl)-4-methylbenzenesulfonamide TOLBUTAMIDE CRYSTALLINE EINECS 200-594-3 Diasulfon Dirastan N-Butyl-N'-toluene-p-sulfonylurea Inwd rectifier K(+) channel Kir3.4 Butamid N-4-Methylbenzolsulfonyl-N-butylurea diabesan Inwd rectifying potassium channel protein TWIK-1 Anti-KCNJ5, C-Terminal antibody produced in rabbit N-(ButylcbaMoyl)-4-MethylbenzenesulfonaMide Drabet 3-butyl-1-(4-methylphenyl)sulfonyl urea Inwd rectifier K channel Kir5.1 TOLBUTAMIDE VETRANAL IRK16 N-Butyl-N'-(4-methylphenylsulfonyl)urea PotassiuM channel Dolipol Diaben [14C]-Tolbutamide N'-4-Methylbenzenesulfonyl-N''-butylurea Potassium channel subfamily K member 1 G protein-activated inwd rectifier potassium channel 4 Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl hls831 Ipoglicone Artosin 1-butyl-3-(4-methylphenyl)sulfonylurea n-butyl-n’-p-toluenesulfonylurea Tolbutamidum MFCD00027169 Willbutamide 1-(p-toluenesulfonyl)-3-n-butyl-urea Cdiac inwd rectifier potassium channel N'-Butyl-N-[(4-methylphenyl)sulfonyl]carbamimidic acid Potassium channel KCNO1 KCNJ16 NCI-C01763 3-butyl-1-(4-methylphenyl)sulfonyl-urea beglucin Inwd rectifier K(+) channel Kir2.1 GIRK4 inwdly rectifying subfamily J member 5 Glyconon inwdly rectifying subfamily J member 2 4-11-00-00396 (Beilstein Handbook Reference) Butamide |
| Description | Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.Target: Potassium ChannelTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Tolbutamide act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Tolbutamide belongs to a class of medications called sulfonylureas. Tolbutamide inhibits both the basal and the cyclic AMP-stimulated protein kinase activities and the IC50 of Tolbutamide is 4 mM. Similar Tolbutamide concentrations are required for half maximal inhibition of in vitro lipolysis induced by hormones (norepinephrine and ACTH) or by dibutyryl cyclic AMP plus theophylline. Tolbutamide also inhibits both soluble and membrane-bound protein kinase from canine heart. The Tolbutamide inhibition of adipose tissue cyclic AMP-dependent protein kinase is one possible explanation for the antilipolytic effects of this drug [1]. Tolbutamide inhibits C6-glioma cell proliferation by increasing Cx43, which correlates with a reduction in pRb phosphorylation due to the up-regulation of the Cdk inhibitors p21 and p27 [2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 430.0±38.0 °C at 760 mmHg |
| Melting Point | 128-130°C |
| Molecular Formula | C12H18N2O3S |
| Molecular Weight | 270.348 |
| Flash Point | 213.9±26.8 °C |
| Exact Mass | 270.103821 |
| PSA | 83.65000 |
| LogP | 2.93 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.557 |
| Stability | Stable. Combustible. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F,Xn |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | YS4550000 |
| HS Code | 2935009090 |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |