485-19-8
485-19-8 structure
- Name: Reticuline
- Chemical Name: reticuline
- CAS Number: 485-19-8
- Molecular Formula: C19H23NO4
- Molecular Weight: 329.390
- Catalog: Natural product Alkaloid
- Create Date: 2018-08-21 22:03:40
- Modify Date: 2026-06-30 23:06:35
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Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1].
| Name | reticuline |
|---|---|
| Synonyms |
1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
2-Methyl-7-hydroxy-6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (S)-Reticuline Coclanoline (S)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol [1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinoline-7-ol 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-, (1S) (1S)-1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol [1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol (±)-Reticuline 2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol 1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol 1-(3-Hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol Reticuline ( ee) |
| Description | Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1]. |
|---|---|
| Related Catalog | |
| Target |
JAK2 STAT3 NF-κB |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 504.9±50.0 °C at 760 mmHg |
| Melting Point | 125-126ºC |
| Molecular Formula | C19H23NO4 |
| Molecular Weight | 329.390 |
| Flash Point | 259.2±30.1 °C |
| Exact Mass | 329.162720 |
| PSA | 62.16000 |
| LogP | 2.09 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.604 |
| Storage condition | -20?C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
|---|
| Precursor 7 | |
|---|---|
| DownStream 10 | |
![[13aS,(-)]-5,8,13,13a-Tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,11-diol structure](https://image.chemsrc.com/caspic/446/483-45-4.png)
![6',7'-dimethoxy-2'-methyl-6,8,3',4'-tetrahydro-2'H-(7rN)-spiro[indeno[4,5-d][1,3]dioxole-7,1'-isoquinoline]-6t,8t-diol structure](https://image.chemsrc.com/caspic/431/56435-41-7.png)
![[6S,(+)]-6-[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one structure](https://image.chemsrc.com/caspic/108/524-46-9.png)