108321-21-7

108321-21-7 structure

Name: Propionyl coenzyme A lithium
Chemical Name: n-Propionyl coenzyme A lithium salt
CAS Number: 108321-21-7
Molecular Formula: C₂₄H₄₀LiN₇O₁₇P₃S
Molecular Weight: 830.53800
Catalog: Research Areas Metabolic Disease
Create Date: 2016-06-07 11:15:55
Modify Date: 2024-01-02 15:51:25
Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms[1][2].

Name	n-Propionyl coenzyme A lithium salt
Synonyms	S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tet rahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphor yl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl ] propanethioate,lithium

Description	Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Propionyl coenzyme A lithium causes toxic effects due to its accumulation and the impact of its metabolism on cell wall synthesis and maintenance in Mycobacterium tuberculosis[1]. Propionyl coenzyme A lithium can be converted to β-hydroxypropionic acid via a peroxisomal enzyme-modified β-oxidation pathway in Arabidopsis[2]. Propionyl coenzyme A lithium causes the formation of propionic acidemia due to its abnormal accumulation, which often occurs in the neonatal developmental stage[3].
References	[1]. Ernesto J Muñoz-Elías, et al. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol. 2006 Jun;60(5):1109-22. [2]. Kerry A Lucas, et al. Peroxisomal metabolism of propionic acid and isobutyric acid in plants. J Biol Chem. 2007 Aug 24;282(34):24980-9. [3]. Oleg A Shchelochkov, et al. Propionic Acidemia. 2012 May 17 [updated 2016 Oct 6]. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	22-26-36
RIDADR	NONH for all modes of transport