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501-94-0

501-94-0 structure
501-94-0 structure
  • Name: 4-Hydroxyphenyl ethanol
  • Chemical Name: 2-(4-hydroxyphenyl)ethanol
  • CAS Number: 501-94-0
  • Molecular Formula: C8H10O2
  • Molecular Weight: 138.16
  • Catalog: Chemical reagent Organic reagent Aromatic alcohol
  • Create Date: 2018-08-21 16:01:36
  • Modify Date: 2024-01-01 19:00:44
  • Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1].
Name 2-(4-hydroxyphenyl)ethanol
Synonyms 4-(2-Hydroxyethyl)phenol
2-(4-Hydroxyphenyl)ethyl Alcohol
4-Hydroxyphenylethanol
β-(4-Hydroxyphenyl)ethanol
4-[(2S)-2-Amino-3-hydroxypropyl]phenol
(S)-4-(2-Amino-3-hydroxypropyl)phenol
b-(4-Hydroxyphenyl)ethanol
Benzenepropanol, β-amino-4-hydroxy-, (βS)-
tyrosinol
4-(2-Hydroxyethyl)benzolol
phenethyl alcohol, 4-hydroxy-
p-Hydroxyphenethyl alcohol
Benzenepropanol, β-amino-4-hydroxy-, (S)-
UNII-1AK4μ3SNX
2-(4-Hydroxyphenyl)ethanol
Ethanol, 2-(4-hydroxyphenyl)-
2-(4-Hydroxyphenyl)ethan-1-ol
(S)-b-Amino-4-hydroxybenzenepropanol
4-hydroxybenzeneethanol
MFCD00002902
β-(p-Hydroxyphenyl)ethanol
4-Hydroxyphenethyl alcohol
EINECS 207-930-8
Benzeneethanol, 4-hydroxy-
p-Hydroxyphenylethanol
4-Hydroxyphenethyl alcohol,Tyrosol,p-HPEA
4-Hydroxyphenylethyl alcohol
b-(p-Hydroxyphenyl)ethanol
4-Hydroxyphenyl ethanol
Tyrosol
Description Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1].
Related Catalog
In Vitro Tyrosol (1.6 mM) significantly increases the cell viability of cultured astrocytes exposed to oxygen glucose deprivation (OGD)[1]. Tyrosol (1.6 mM) attenuates the released TNF-α and IL-6 level from astrocyte via regulating Janus N-terminal kinase (JNK) [1]. The reduction of cytokines from astrocyte might be due to its inhibition of astrocyte activation and regulation of STAT3 signaling pathway since Tyrosol (1.6 mM) attenuates the expression level of GFAP (glial fibrillary acidic protein) and the phosphorylation of STAT3[1]. Tyrosol prevents the degradation of IκBα and the increase of IκBα phosphorylation in astrocytes exposed to OGD, which leads to the suppression of NF-κB function during ischemia[1].
In Vivo Sub-plantar injection of carrageenan causes a noticeable increase in paw thickness, reaching a peak after 2 h post-injection. This effect is reduced when Tyrosol (0.5 mg/kg) or Tyrosol-sulphate is injected prior to the treatment with carrageenan. Similar AUC values for paw oedema are obtained after the administration of Tyrosol at a dose of 0.5 mg/kg and Tyrosol-sulphate at a dose of 0.1 mg/kg.
References

[1]. Luo G, et al. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation. Neurochem Int. 2018 Dec;121:140-145.

[2]. Muriana FJG, et al. Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells. Food Funct. 2017 Aug 1;8(8):2905-2914.
Density 1.2±0.1 g/cm3
Boiling Point 375.2±27.0 °C at 760 mmHg
Melting Point 89-92 °C(lit.)
Molecular Formula C8H10O2
Molecular Weight 138.16
Flash Point 180.7±23.7 °C
PSA 40.46000
LogP 0.04
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.598
Water Solubility slightly soluble
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2907299090
HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Chemsrc provides CAS#:501-94-0 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 501-94-0 | Chemsrc address: https://m.chemsrc.com/en/baike/667406.html

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