Henan Tianfu Chemical Co., Ltd.
China
Product Name: beta-Diphosphopyridine nucleotide
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53-84-9

53-84-9 structure

Name: NAD+
Chemical Name: NAD zwitterion
CAS Number: 53-84-9
Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
Molecular Weight: 663.425
Catalog: API Vitamins and minerals Vitamin B drugs
Create Date: 2018-04-08 08:00:00
Modify Date: 2026-06-30 18:37:54
NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.

Name	NAD zwitterion
Synonyms	cozymasei b-Diphosphopyridine Nucleotide β-DPN, β-NAD, Coenzyme1, Cozymase, Diphosphopyridine nucleotide, DPN, NAD, Nadide BETA-NICOTINAMIDE ADENINE DINUCL. DI-HYD R.,PGE 10 FLASKS beta-Diphosphopyrid MFCD00036253 B-NICOTINAMIDE ADENINE DINUCLEOTIDEFROM YEAST beta-diphosphopyridine Diphosphopyridinnucleotid BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE M ONOHYDRATE F.YEAST Cozymase Hydrate,oxidized form β-DPN pyridinium,3-cbamoyl-1-beta-d-ribofuranosyl-,hydroxide,5’-esterwithadenosine5’-5’-(trihydrogenpyrophosphate),innersalt beta-Diphosphopyridi β-DPN, β-NAD, Coenzyme1, Cozymase, Diphosphopyridine nucleotide, DPN, Nadide NAD, APPROX. , LYO sine5’-5’-(trihydrogenpyrophosphate),innersalt NICOTINAMIDE ADENINE DINUCLEOTIDE (OXIDISED) extrapure B-NICOTINAMIDE ADENINE DINUCLEOTIDESIGM AULTRA FROM beta-Diphosphopyridine nucleotide beta-Nicotinamide adenine dinucleotide β-Diphosphopyridine Nucleotide Hydrate,oxidized form beta-Nicotinamide adenine dinucleotide Hydrate from yeast β-Nicotinamide adenine dinucleotide hydrate,β-DPN, β-NAD, Coenzyme1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide BETA-NICOTINAMIDE ADENINE DINUCLEOTI Nicotinamideadeninedinucleotidefreeacid(NAD) BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE D IHYDRATE F. YEAST Adenosine5’-(trihydrogendiphosphate),P’.fwdw.5’-esterwith3-(aminocbonyl)-1-.beta.-D-ribofuranosylpyridinium,innersalt nicotineamideadeninedinucleotide B-NICOTINAMIDE ADENINE DINUCLEOTIDEAD E AA-I Nicotinamide adenine dinucleotide(NAD+) monosodium salt B-NICOTINAMIDE ADENINE DINUCLEOTIDEAPPR OX. FRO Codehydrogenase Adenosine5'-(trihydrogen diphosphate), P'5'-ester with 3-(aminocbonyl)-1-b-D-ribofuranosylpyridinium, inner salt adenosine5’-(trihydrogendiphosphate),p’.fwdw.’-esterwith3-(aminocbonyl 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'®5'-ester with Adenosine 5'-(Trihydrogen Pyrophosphate) Inner Salt beta-Diphosphopyridine nucleotide β-Nicotinamide adenine dinucleotide hydrate [5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-[[5-(5-cbamoylpyridin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-oxido-phosphoryl]oxy-phosphinic acid DPN adenine-nicotinamidedinucleotide pyridinium,3-cbamoyl-1-beta-d-ribofuranosyl-,hydroxide,5’-esterwithadeno POTASSIUM IODATE-IODIDE SOLN enzopride Coenzyme I Hydrate,oxidized form [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-cbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl Diphosphopyridine nucleotide eotide β-Nicotinamide adenine dinucleotide,β-DPN, β-NAD, Coenzyme1, Cozymase, DPN, Diphosphopyridine nucleotide, Nadide β-Nicotinamide adenine dinucleotide beta-Nicotinamide adenine dinucleotide hydrate B-NAD NAD, APPROX. , ADE I, LYO EINECS 200-184-4 B-NICOTINAMIDE ADENINE DINUCLEOTIDEAPPR OX. CRY β-NAD, β-Nicotinamide adenine dinucleotide trihydrate beta-Nicotinamide adenine dinucleotide hydrate Vetec(TM) ade, >= Oxidized diphosphopyridine nucleotide NICOTINAMIDE ADENINE DI-NUCLEOTIDE ANALYTICAL ADE Adenosine 5'-(trihydrogen diphosphate), P'->5'-ester with 3-(aminocbonyl)-1-b-D-ribofuranosylpyridinium hydroxide, inner salt B-NICOTINAMIDE ADENINE DINUCLEOTIDE CRYSTALLIN Cozymasei(NAD+) β-NAD Hydrate,oxidized form Adenine-D-ribose-phosphate-phosphate-D-ribose-nicotinamide β-Nicotinamide Adenine Dinuclotide NAD Food ade b-Nicotinamide Adenine Dinucleotide β-DPN Hydrate,oxidized form Adenosine 5'-(Trihydrogen Diphosphate) P'®5'-ester with 3-(Aminocarbonyl)-1-b-D-ribofuranosylpyridinium hydroxide Inner Salt NAD β-Nicotinamide Adenine Dinucleotide Hydrate,oxidized form NICOTINAMIDE ADENINE DINUCLEOTIDE, BETA-(P) B-NICOTINAMIDE ADENINE DINUCLEOTIDE*FROM YEAST CELL beta-Diphosphopyridine nucleotide (NAD) ARPPRN b-NAD Cozymase OSTEOPONTIN, GST FUSION )-1-beta-d-ribofuranosylpyridiniumhydroxide,innersalt β-NAD β-DPNβ-NAD

Description	NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Saccharides and Glycosides
Target	Human Endogenous Metabolite
In Vitro	NAD+ is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NAD+ is the oxidized form of NADH[1]. NAD+ is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (Nadide) [2].
In Vivo	Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[3].
References	[1]. Viollet, B., et al., Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond), 2012. 122(6): p. 253-70. [2]. Brandt, U., Energy converting NADH:quinone oxidoreductase (complex I). Annu Rev Biochem, 2006. 75: p. 69-92. [3]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.

Melting Point	140 - 142ºC
Molecular Formula	C₂₁H₂₇N₇O₁₄P₂
Molecular Weight	663.425
Exact Mass	663.109131
PSA	340.71000
LogP	-5.72

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU3450000

CHEMICAL NAME :: Pyridinium, 3-carbamoyl-1-beta-D-ribofuranosyl-, hydroxide, 5'-ester with adenosine 5'- 5'-(trihydrogen pyrophosphate), inner salt

CAS REGISTRY NUMBER :: 53-84-9

BEILSTEIN REFERENCE NO. :: 3584133

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H27-N7-O14-P2

MOLECULAR WEIGHT :: 663.49

WISWESSER LINE NOTATION :: T56 BN DN GN INJ FZ B- BT5OJ CQ DQ E1OPWOPWO1- BT5OTJ CQ DQ E- AT6KJ CVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,327,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3384 No. of Facilities: 499 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3384 No. of Facilities: 1731 (estimated) No. of Industries: 5 No. of Occupations: 13 No. of Employees: 26664 (estimated) No. of Female Employees: 19782 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H371
Precautionary Statements	P260
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn,F,Xi
Risk Phrases	R36
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UU3450000
HS Code	29349990

Precursor 9
58-68-4 1094-61-7 24558-92-7 18784-01-5
78687-39-5 78687-38-4 6450-77-7 61-19-8
56-65-5
DownStream 8
36791-04-5 22596-06-1 98-92-0 20762-30-5
61-19-8 73-24-5 58-64-0 119340-53-3