Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H,3H-Furo[3,4-c]furan,1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1R,3aS,4R,6aS)-
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Purity: 98.0%
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Contact: Ms Wang

526-06-7

526-06-7 structure

Name: Eudesmin
Chemical Name: 1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1.α.,3a.α.,4.α.,6a.α.)-(-)
CAS Number: 526-06-7
Molecular Formula: C₂₂H₂₆O₆
Molecular Weight: 386.438
Catalog: Natural product Lignans
Create Date: 2018-06-24 13:28:08
Modify Date: 2024-01-08 18:11:42
Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1].

Name	1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1.α.,3a.α.,4.α.,6a.α.)-(-)
Synonyms	Pinoresinol dimethyl ether Eudesamin,Eudesmin (1S,3aR,4S,6aR)-1,4-Bis(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan 1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1S,3aR,4S,6aR)- (7S,7’S,8R,8’R)-eudesmin (1S,3aR,4S,6aR)-1,4-bis(3,4-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan eudesmin

Description	Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)
Target	S6K1[1]
In Vitro	Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment[1].
References	[1]. Ki Hong Nam, et al. Eudesmin Impairs Adipogenic Differentiation via Inhibition of S6K1 Signaling Pathway. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1148-1153.

Precursor 0
DownStream 3
93-07-2 3395-03-7 67560-68-3