- BioBioPha
- China
- Product Name: Momordicoside G
- Price: ￥4650.0/5mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Momordicoside G
- Price: ￥5600.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Momordicoside G
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: MOMORDICOSIDE G
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
81371-54-2
81371-54-2 structure
- Name: Momordicoside G
- Chemical Name: (1R,4S,5S,8R,9R,12S,13S,16S)-8-[(2R,4E)-6-Methoxy-6-methyl-4-hepten-2-yl]-5,9,17,17-tetramethyl-18-oxapentacyclo[10.5.2.01,13.04,12.05,9]nonadec-2-en-16-yl β-D-allopyranoside
- CAS Number: 81371-54-2
- Molecular Formula: C37H60O8
- Molecular Weight: 632.867
- Catalog: Natural product Moss
- Create Date: 2017-11-14 17:08:34
- Modify Date: 2024-01-03 17:37:34
-
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury[1].
| Name | (1R,4S,5S,8R,9R,12S,13S,16S)-8-[(2R,4E)-6-Methoxy-6-methyl-4-hepten-2-yl]-5,9,17,17-tetramethyl-18-oxapentacyclo[10.5.2.01,13.04,12.05,9]nonadec-2-en-16-yl β-D-allopyranoside |
|---|---|
| Synonyms |
(1R,4S,5S,8R,9R,12S,13S,16S)-8-[(2R,4E)-6-Methoxy-6-methyl-4-hepten-2-yl]-5,9,17,17-tetramethyl-18-oxapentacyclo[10.5.2.0.0.0]nonadec-2-en-16-yl β-D-allopyranoside
momordicoside G β-D-Allopyranoside, (3S,5R,8S,9S,10S,13R,14S,17R)-1,3,4,8,10,11,12,13,14,15,16,17-dodecahydro-17-[(1R,3E)-5-methoxy-1,5-dimethyl-3-hexen-1-yl]-4,4,13,14-tetramethyl-5,9-(epoxymethano)-2H-cyclopenta [a]phenanthren-3-yl Momorcharaside A |
| Description | Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 用 10 ng/mL LPS 或 10 ng/mL IL-10 刺激 Raw264.7 巨噬细胞 24 h，获得 M1 样 (iNOS+) 和 M2样 (精氨酸酶+) 巨噬细胞[1]。 Momordicoside G (10-40 μM; 24 h) 抑制 M1 巨噬细胞的细胞活力，对 M2 巨噬细胞无抑制作用。Momordicoside G (40 μM) 体外诱导 M1 巨噬细胞凋亡，降低 NO 水平，增加 IL-12、IL-10 和 TGF-β 水平[1]。 Momordicoside G (40 μM) 可抑制细胞自噬相关标志物 LC3-B 的蛋白水平[1]。 Cell Viability Assay[1] Cell Line: M1 macrophages, M2 macrophages Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 24 hours Result: Selectively decreased the cell viability of M1 macrophages, instead of M2 macrophages. |
| In Vivo | ICR 小鼠的肺部致癌模型由氨基甲酸乙酯 (HY-B1207) (600 mg/kg；腹腔注射；每周一次，持续 4 或 8 周) 诱导，或由 LPS (HY-D1056) (2 mg/kg；气管内施用) 和 4 mg/小鼠 IEC (腹腔注射) 诱导[1]。 Momordicoside G (50 mg/kg；口服；每天一次，持续 4 或 8 周) 在小鼠肺致癌模型中可预防氨基甲酸乙酯引起的肺损伤和癌病变[1]。 Momordicoside G (50 mg/kg；口服；每天一次，持续 2 周) 在 LPS 诱导的肺损伤模型中促进肺损伤修复[1]。 Animal Model: Mouse lung carcinogenic model: Urethane-induced lung carcinogenic model and LPS-induced lung injury model[1] Dosage: 50 mg/kg Administration: Oral gavage; once daily for 4 or 8 weeks Result: Affected inflammasome and cytokines during urethane-induced lung injury and carcinoma lesions. Exhibits macrophage-regulating capacity in LPS-induced lung injury model. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 711.4±60.0 °C at 760 mmHg |
| Molecular Formula | C37H60O8 |
| Molecular Weight | 632.867 |
| Flash Point | 384.0±32.9 °C |
| Exact Mass | 632.428833 |
| PSA | 117.84000 |
| LogP | 5.40 |
| Vapour Pressure | 0.0±5.2 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Hazard Codes | Xi |
|---|