Kushenol K

Modify Date: 2024-01-02 17:03:45

Kushenol K structure	Common Name	Kushenol K
	CAS Number	101236-49-1	Molecular Weight	472.527
	Density	1.3±0.1 g/cm3	Boiling Point	722.4±60.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₂O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	242.4±26.4 °C

Use of Kushenol K

Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].

Name	Kushenol K
Synonym	More Synonyms

Description	Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM[1]. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM)[2]. Kushenol K also inhibits the activity of SGLT1 and SGLT2[3].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT
Target	HSV-2:147 μM (EC50) CYP3A4:1.35 μM (Ki) SGLT
In Vitro	When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50 values of 1.62 µM[1]. At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].
References	[1]. Yannan Li, et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36. [2]. E R Woo, et al. A new prenylated flavonol from the roots of Sophora flavescens. J Nat Prod. 1998 Dec;61(12):1552-4. [3]. Seizo Sato, et al. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9.

Density	1.3±0.1 g/cm3
Boiling Point	722.4±60.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₂O₈
Molecular Weight	472.527
Flash Point	242.4±26.4 °C
Exact Mass	472.209717
LogP	3.81
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.614

4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-

(2R,3S)-2-(2,4-Dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-2-isopropenyl-5-methylhexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one

(2R,3S)-2-(2,4-dihydroxyphenyl)-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl]-5-methoxy-2,3-dihydro-4H-chromen-4-one

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Kushenol K
Price: ￥4708.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Kushenol K
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Kushenol K
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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