PF-00299804

Modify Date: 2024-01-09 20:48:08

PF-00299804 Structure
PF-00299804 structure
Common Name PF-00299804
CAS Number 1042385-75-0 Molecular Weight 487.95
Density N/A Boiling Point N/A
Molecular Formula C24H27ClFN5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PF-00299804


Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan-ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC)[1].

 Names

Name (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide,hydrate
Synonym More Synonyms

 PF-00299804 Biological Activity

Description Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan-ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC)[1].
Related Catalog
References

[1]. Lau SCM, et al. Dacomitinib in the Management of Advanced Non-Small-Cell Lung Cancer. Drugs. 2019 Jun;79(8):823-831.  

 Chemical & Physical Properties

Molecular Formula C24H27ClFN5O3
Molecular Weight 487.95
Exact Mass 487.178650
PSA 92.10000
LogP 5.75120

 Safety Information

Hazard Codes Xi

 Synonyms

(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}-4-(1-piperidinyl)-2-butenamide hydrate (1:1)
Dacomitinib [USAN:INN]
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)-, hydrate (1:1)
(2E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide, hydrate (1:1)
UNII-5092U85G58
2-Butenamide,N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxy-6-quinazolinyl)-4-(1-piperidinyl)-,hydrate (1:1),(2E)
Dacomitinib
dacomitinib hydrate
Dacomitinib hydrate (JAN)
(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide monohydrate
Dacomitinib monohydrate
(2E)-N-(4-(3-Chloro-4-fluorophenyl)amino)7-methoxyquinazolin-6-yl)4-(piperidin-1-yl)but-2-enamide monohydrate
PF-00299804
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