[Pro9]-Substance P

Modify Date: 2024-01-06 19:11:52

Use of [Pro9]-Substance P

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1].

Name	arg-pro-lys-pro-gln-gln-phe-phe-pro-leu-met-nh2
Synonym	More Synonyms

Description	[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC50 of 0.93 nM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK1:0.93 nM (EC50)
In Vitro	[3H][Pro9]-Substance P can be used as a radio ligand for NK- 1 binding sites[1]. [Pro9]-Substance P stimulates inositol phosphate formation with an efficacy only slightly lower than that of SP (EC50 values of 0.93 ± 0.07 and 0.45 ± 0.06 nM, respectively) on primary cultures of newborn mouse cortical glial cells[1].

WGK Germany	3

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2

9-L-PROLINE-SUBSTANCE P

substance P,Pro(9)

RPKPQQFFPLM-NH2

[TYR9]-SUBSTANCE P

[Pro9]SP

[PRO9] SUBSTANCE P

L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-L-Pro-L-Leu-L-Met-NH2

pro(9)-substance

[Pro9]-Substance P

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