Tr-PEG2-OH
Modify Date: 2024-01-14 09:15:39
Tr-PEG2-OH structure
|
Common Name | Tr-PEG2-OH | ||
|---|---|---|---|---|
| CAS Number | 105589-77-3 | Molecular Weight | 348.43500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tr-PEG2-OHTr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | 2-(2-trityloxyethoxy)ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
| Molecular Formula | C23H24O3 |
|---|---|
| Molecular Weight | 348.43500 |
| Exact Mass | 348.17300 |
| PSA | 38.69000 |
| LogP | 4.00400 |
| Hazard Codes | Xi |
|---|
|
~82%
Tr-PEG2-OH CAS#:105589-77-3 |
| Literature: Gothard, Chris M.; Grzybowski, Bartosz A. Synthesis, 2012 , vol. 44, # 5 p. 717 - 722 |
|
~%
Tr-PEG2-OH CAS#:105589-77-3 |
| Literature: Fordyce; Lovell; Hibbert Journal of the American Chemical Society, 1939 , vol. 61, p. 1905,1908 |
|
~%
Tr-PEG2-OH CAS#:105589-77-3 |
| Literature: Altenburger, Jean-Michel; Lebeau, Luc; Mioskowski, Charles; Schirlin, Daniel Helvetica Chimica Acta, 1992 , vol. 75, # 8 p. 2538 - 2544 |
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~%
Tr-PEG2-OH CAS#:105589-77-3 |
| Literature: Komiotis; Currie; LeBreton; Venton Synthetic Communications, 1993 , vol. 23, # 4 p. 531 - 534 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| diethylene glycol monotrityl ether |
| diethylene glycol monotritylate |
| 7,7,7-triphenyl-2,5-dioxaheptan-1-ol |
| monotritylated diethylene glycol |
| 7,7,7-Triphenyl-3,6-dioxaheptanol |