Ezetimibe-d4

Modify Date: 2024-01-04 17:00:33

Ezetimibe-d4 Structure
Ezetimibe-d4 structure
Common Name Ezetimibe-d4
CAS Number 1093659-89-2 Molecular Weight 413.45
Density N/A Boiling Point N/A
Molecular Formula C24H17D4F2NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ezetimibe-d4


Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

 Names

Name Ezetimibe-d4
Synonym More Synonyms

 Ezetimibe-d4 Biological Activity

Description Ezetimibe-d4 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

[3]. Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.

 Chemical & Physical Properties

Molecular Formula C24H17D4F2NO3
Molecular Weight 413.45
Exact Mass 413.17400
PSA 60.77000
LogP 4.95330

 Synonyms

Ezetimibe-d4