Androgen receptor modulators 1

Modify Date: 2024-01-07 06:02:15

Androgen receptor modulators 1 Structure
Androgen receptor modulators 1 structure
Common Name Androgen receptor modulators 1
CAS Number 1114546-03-0 Molecular Weight 298.26
Density N/A Boiling Point N/A
Molecular Formula C14H13F3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Androgen receptor modulators 1


Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].

 Names

Name Androgen receptor modulators 1

 Androgen receptor modulators 1 Biological Activity

Description Androgen receptor modulators 1 is a selective androgen receptor modulator (SARM). Androgen receptor modulators 1 has strong agonistic activities with an EC50 of 4.7 nM[1].
Related Catalog
Target

EC50: 4.7 nM (SARM)[1]

In Vitro Androgen receptor modulators 1 (Compounds 2f) induces sexual behavior at the minimal dose (0.5 mg/kg/day, qd, po). It could act as androgen agonist on the CNS[1]. Androgen receptor modulators 1 shows good metabolic stabilities with little species difference between rat, dog, mouse, monkey and human[1].
References

[1]. Aikawa K, et al. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate. Bioorg Med Chem. 2017 Jul 1;25(13):3330-3349.

 Chemical & Physical Properties

Molecular Formula C14H13F3N2O2
Molecular Weight 298.26
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