NALTRIBEN MESYLATE

Modify Date: 2024-01-05 10:28:22

NALTRIBEN MESYLATE Structure
NALTRIBEN MESYLATE structure
Common Name NALTRIBEN MESYLATE
CAS Number 111555-58-9 Molecular Weight 415.48
Density 1.5 g/cm3 Boiling Point 605.3ºC at 760 mmHg
Molecular Formula C26H25NO4 Melting Point N/A
MSDS N/A Flash Point 319.9ºC

 Use of NALTRIBEN MESYLATE


Naltriben is a selective δ2-opioid receptor antagonist and TRPM7 activator. Naltriben enhances glioblastoma cell migration and invasion. Naltriben can be used in research into neurological diseases and cancer[1][2].

 Names

Name Naltriben
Synonym More Synonyms

 NALTRIBEN MESYLATE Biological Activity

Description Naltriben is a selective δ2-opioid receptor antagonist and TRPM7 activator. Naltriben enhances glioblastoma cell migration and invasion. Naltriben can be used in research into neurological diseases and cancer[1][2].
Related Catalog
References

[1]. Lever JR, et al. Selective in vivo binding of [3H]naltriben to delta-opioid receptors in mouse brain. Eur J Pharmacol. 1998 Jun 5;350(2-3):335-44.  

[2]. Wong R, et al. Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells. Oncotarget. 2017 Feb 14;8(7):11239-11248.  

 Chemical & Physical Properties

Density 1.5 g/cm3
Boiling Point 605.3ºC at 760 mmHg
Molecular Formula C26H25NO4
Molecular Weight 415.48
Flash Point 319.9ºC
Exact Mass 511.16600
PSA 128.82000
LogP 4.36020
Vapour Pressure 1.67E-15mmHg at 25°C
Index of Refraction 1.779

 Synthetic Route

~81%

NALTRIBEN MESYLATE Structure

NALTRIBEN MESYLATE

CAS#:111555-58-9

Literature: Portoghese; Sultana; Nagase; Takemori Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 281 - 282

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NALTRIBEN MESYLATE Structure

NALTRIBEN MESYLATE

CAS#:111555-58-9

Literature: PROGENICS PHARMACEUTICALS, INC Patent: WO2009/67275 A1, 2009 ; Location in patent: Page/Page column 140-141 ; WO 2009/067275 A2

 Synonyms

naltrindole benzofuran
C26H25NO4
NTB
HMS2089G18