Naltriben mesylate

Modify Date: 2024-01-10 21:21:59

Naltriben mesylate structure	Common Name	Naltriben mesylate
	CAS Number	122517-78-6	Molecular Weight	511.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₉NO₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Naltriben mesylate

Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2].

Name	naltriben methanesulfonate
Synonym	More Synonyms

Description	Naltriben mesylate is a potent delta-2 receptor-selective antagonist, with Kis are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively. Naltriben mesylate selectively attenuates alcohol intake in rats bred for alcohol preference[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vivo	The hypothermia caused by SNC-80 (35 mg/kg, im) is blocked by a delta2 antagonist, Naltriben (2.5 mg/kg; sc; Sprague-Dawley rats weighing 100-125 g)[2].
References	[1]. Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52(1):153-159. [2]. Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049(1):61-69.