NSC 370284
NSC 370284 structure
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Common Name | NSC 370284 | ||
|---|---|---|---|---|
| CAS Number | 116409-29-1 | Molecular Weight | 387.42600 | |
| Density | 1.276g/cm3 | Boiling Point | 515.2ºC at 760mmHg | |
| Molecular Formula | C21H25NO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 265.4ºC | |
Use of NSC 370284NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5. NSC-370284 has low cytotoxicity[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5. NSC-370284 has low cytotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
STAT3 STAT5 TET1 |
| In Vitro | NSC-370284 (0-500 nM；24 h 或 48 h) 通过靶向 STAT3/5 抑制 MONOMAC-6、THP-1、KOCL-48 和 KASUMI-1 急性髓系白血病 (AML) 细胞活力。NSC-370284 显著下调 TET1 转录水平[1]。 Cell Viability Assay[1] Cell Line: AML cell lines including MONOMAC-6, THP-1, KOCL-48, and KASUMI-1 Concentration: 0, 25, 50, 200 or 500 nM Incubation Time: 24 h or 48 h Result: Showed inhibitory for AML cells viability and TET1 transcription. |
| In Vivo | NSC-370284 (2.5 mg/kg；腹腔注射，每天一次，持续 10 天) 改善了 MLL-AF9 急性髓系白血病 (AML) 小鼠模型外周血 (PB)、骨髓 (BM)、脾和肝组织的病理形态学[1]。 Animal Model: C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice[1]. Dosage: 2.5 mg/kg. Administration: Intraperitoneal injection, once daily, for 10 days. Result: Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.276g/cm3 |
|---|---|
| Boiling Point | 515.2ºC at 760mmHg |
| Molecular Formula | C21H25NO6 |
| Molecular Weight | 387.42600 |
| Flash Point | 265.4ºC |
| Exact Mass | 387.16800 |
| PSA | 69.62000 |
| LogP | 3.26980 |
| Vapour Pressure | 3.09E-11mmHg at 25°C |
| Index of Refraction | 1.598 |
| InChIKey | QCXGNLZKUHBIHD-UHFFFAOYSA-N |
| SMILES | COc1cc(C(c2cc3c(cc2O)OCO3)N2CCCC2)cc(OC)c1OC |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~90%
NSC 370284 CAS#:116409-29-1 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 25, # 1 p. 89 - 96 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
|---|---|
| DownStream 10 | |
![6-ethoxy-6-methyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene structure](https://image.chemsrc.com/caspic/275/116409-28-0.png)
CAS#:116409-28-0![6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene structure](https://image.chemsrc.com/caspic/013/116409-22-4.png)
CAS#:116409-22-4![1-[7-methyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine structure](https://image.chemsrc.com/caspic/351/116409-04-2.png)
CAS#:116409-04-2![7-methyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-ol structure](https://image.chemsrc.com/caspic/313/116409-05-3.png)
CAS#:116409-05-3![1-[6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine structure](https://image.chemsrc.com/caspic/089/116409-20-2.png)
CAS#:116409-20-2![6-methyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-ol structure](https://image.chemsrc.com/caspic/361/116409-26-8.png)
CAS#:116409-26-8![1-[6-methyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromen-7-yl]ethanone structure](https://image.chemsrc.com/caspic/254/117233-19-9.png)
CAS#:117233-19-9
CAS#:117211-85-5
CAS#:116409-24-6![1-[6-methoxy-6-methyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-7-yl]ethanone structure](https://image.chemsrc.com/caspic/165/117211-88-8.png)
CAS#:117211-88-8This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Es...
Source: ChEMBL
Target: Protein disulfide-isomerase
External Id: CHEMBL4729810
|
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Name: Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after...
Source: ChEMBL
Target: U-87 MG
External Id: CHEMBL4729814
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Name: Alphascreen assay for small molecules abrogating mHTT-CaM Interaction
Source: 24983
Target: Huntingtin
External Id: KUHTS-Muma KU-CaM-Htt INH-01
|
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: SMILES notation of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is COc1cc(C(c2cc3c(cc2O)OCO3)N2CCCC2)cc(OC)c1OC. |
| Q: What is the polar surface area (PSA) of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: Polar surface area (PSA) of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is 69.62000. |
| Q: What is the InChIKey of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: InChIKey of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is QCXGNLZKUHBIHD-UHFFFAOYSA-N. |
| Q: What are the uses of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: Main uses of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol: NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5. NSC-370284 has low cytotoxicity[1]. |
| Q: What is the English name of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: The English name of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol. |
| Q: What are the downstream products of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: Related downstream products(CAS) of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol: 116409-28-0;116409-22-4;116409-04-2;116409-05-3;116409-20-2;116409-26-8;117233-19-9;117211-85-5;116409-24-6;117211-88-8. |
| Q: What is the molecular formula of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: Molecular formula of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is C21H25NO6. |
| Q: What is the Chinese name of 116409-29-1? |
| A: Chinese name of 116409-29-1 is 116409-29-1. |
| Q: What is the molecular weight of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: Molecular weight of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is 387.42600. |
| Q: What is the CAS number of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol? |
| A: CAS number of 6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol is 116409-29-1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |