PF-4618433
Modify Date: 2024-01-10 17:56:00
PF-4618433 structure
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Common Name | PF-4618433 | ||
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| CAS Number | 1166393-85-6 | Molecular Weight | 445.517 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 587.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H27N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 309.2±30.1 °C | |
Use of PF-4618433PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2]. |
| Name | 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-((pyridin-3-yloxy)methyl)-1H-pyrazol-3-yl)urea |
|---|---|
| Synonym | More Synonyms |
| Description | PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2]. |
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| Related Catalog | |
| Target |
IC50: 637 nM (PYK2)[1] |
| In Vitro | PF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner[1]. PF-4618433 (0.1-0.3 μM; 24 hours) enhances osteoblast proliferation[2]. PF-4618433 (0.0125-0.3 μM; 14 or 21 days) enhances calcium deposition at the concentrations of 0.1 and 0.3 μM[2]. Cell Proliferation Assay[2] Cell Line: Murine bone marrow-derived mesenchymal stem cells (BMSC) Concentration: 0.1, 0.3 μM Incubation Time: 24 hours Result: Increased cell proliferation activity significantly when compared to the untreated or control group. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 587.6±50.0 °C at 760 mmHg |
| Molecular Formula | C24H27N7O2 |
| Molecular Weight | 445.517 |
| Flash Point | 309.2±30.1 °C |
| Exact Mass | 445.222626 |
| PSA | 109.75000 |
| LogP | 4.86 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.649 |
| 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(3-((pyridin-3-yloxy)methyl)-1H-pyrazol-5-yl)urea |
| 1-[1-(4-Methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]-3-{3-[(3-pyridinyloxy)methyl]-1H-pyrazol-5-yl}urea |
| Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[3-[(3-pyridinyloxy)methyl]-1H-pyrazol-5-yl]- |
| PF4618433 |