LDN 214117
Modify Date: 2024-01-10 13:07:45
LDN 214117 structure
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Common Name | LDN 214117 | ||
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| CAS Number | 1627503-67-6 | Molecular Weight | 419.516 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 567.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H29N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 297.3±30.1 °C | |
Use of LDN 214117LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).IC50 value: 22 nM(ALK2) [1]Target: ALK2 inhibitorLDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and lowcytotoxicity. LDN-214117 may be useful as highly selectiveprobes of BMP-mediated cellular physiology that may provide auseful complement to the dorsomorphin class of compounds. Furthermore, this class of BMP inhibitors offers a structurallydistinct template for the development of therapeutics for thetreatment of BMP signaling-mediated diseases such as FOP. |
| Name | 1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazine |
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| Synonym | More Synonyms |
| Description | LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).IC50 value: 22 nM(ALK2) [1]Target: ALK2 inhibitorLDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and lowcytotoxicity. LDN-214117 may be useful as highly selectiveprobes of BMP-mediated cellular physiology that may provide auseful complement to the dorsomorphin class of compounds. Furthermore, this class of BMP inhibitors offers a structurallydistinct template for the development of therapeutics for thetreatment of BMP signaling-mediated diseases such as FOP. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.9±50.0 °C at 760 mmHg |
| Molecular Formula | C25H29N3O3 |
| Molecular Weight | 419.516 |
| Flash Point | 297.3±30.1 °C |
| Exact Mass | 419.220886 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.573 |
| Storage condition | 2-8°C |
| 1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazine |
| Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]- |
| LDN-214117 |