LDN-75654

Modify Date: 2024-01-06 19:36:53

LDN-75654 Structure
LDN-75654 structure
Common Name LDN-75654
CAS Number 912798-81-3 Molecular Weight 282.698
Density 1.3±0.1 g/cm3 Boiling Point 327.9±42.0 °C at 760 mmHg
Molecular Formula C13H12ClFN2O2 Melting Point N/A
MSDS N/A Flash Point 152.1±27.9 °C

 Use of LDN-75654


LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM; Emax 186%), increases SMN protein in spinal cord and brain in mice.

 Names

Name N-(3-Chloro-4-fluorophenyl)-5-isopropyl-1,2-oxazole-3-carboxamide
Synonym More Synonyms

 LDN-75654 Biological Activity

Description LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM; Emax 186%), increases SMN protein in spinal cord and brain in mice.
References References 1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610. View Related Products by Target SMN2 Modulator

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 327.9±42.0 °C at 760 mmHg
Molecular Formula C13H12ClFN2O2
Molecular Weight 282.698
Flash Point 152.1±27.9 °C
Exact Mass 282.057129
LogP 3.51
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.582

 Synonyms

3-Isoxazolecarboxamide, N-(3-chloro-4-fluorophenyl)-5-(1-methylethyl)-
N-(3-Chloro-4-fluorophenyl)-5-isopropyl-1,2-oxazole-3-carboxamide
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