CP-66248
Modify Date: 2024-01-09 23:45:02
CP-66248 structure
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Common Name | CP-66248 | ||
|---|---|---|---|---|
| CAS Number | 120210-48-2 | Molecular Weight | 320.75 | |
| Density | 1.58g/cm3 | Boiling Point | 523.9ºC at 760mmHg | |
| Molecular Formula | C14H9ClN2O3S | Melting Point | 230° (dec) | |
| MSDS | Chinese USA | Flash Point | 270.7ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CP-66248Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. |
| Name | tenidap |
|---|---|
| Synonym | More Synonyms |
| Description | Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. |
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| Related Catalog | |
| Target |
COX-1:0.03 μM (IC50) COX-2:1.2 μM (IC50) |
| References |
| Density | 1.58g/cm3 |
|---|---|
| Boiling Point | 523.9ºC at 760mmHg |
| Melting Point | 230° (dec) |
| Molecular Formula | C14H9ClN2O3S |
| Molecular Weight | 320.75 |
| Flash Point | 270.7ºC |
| Exact Mass | 320.00200 |
| PSA | 111.87000 |
| LogP | 4.01840 |
| Appearance of Characters | faint yellow to dark yellow |
| Vapour Pressure | 7.42E-13mmHg at 25°C |
| Index of Refraction | 1.756 |
| Storage condition | Store at +4°C |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
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Tenidap decreases IL-8 and monocyte chemotactic peptide-1 (MCP-1) mRNA expression in the synovial tissue of rabbits with antigen arthritis and in cultured synovial cells.
Clin. Exp. Immunol. 111(3) , 588-96, (1998) Since IL-8 and MCP-1 are chemoattractant proteins that participate in the recruitment of inflammatory cells into the arthritic joint, we examined the effects of tenidap, a new anti-inflammatory drug o... |
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The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: inhibition by tenidap and benzamil and effect of temperature on transport rate and stoichiometry.
Pflugers Arch. 442(5) , 709-17, (2001) In the present experiments we expressed the rat kidney Na+-HCO3- cotransporter (rkNBC) in Xenopus laevis oocytes to reinvestigate the flux coupling ratio under improved measuring conditions. Essential... |
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Tenidap: not just another NSAID?
Ann. Rheum. Dis. 55(2) , 79-82, (1996)
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| TENIDAP |
| Tenidapum |
| (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide |
| IL-6+Tenidap |
| (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide CP 66248 |