120210-48-2

120210-48-2 structure

Name: CP-66248
Chemical Name: tenidap
CAS Number: 120210-48-2
Molecular Formula: C₁₄H₉ClN₂O₃S
Molecular Weight: 320.75
Catalog: API Antineoplastic agents Tinic antineoplastic agents
Create Date: 2018-08-11 17:32:49
Modify Date: 2024-01-09 23:45:02
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2].

Name	tenidap
Synonyms	TENIDAP Tenidapum (3Z)-5-chloro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide IL-6+Tenidap (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide CP 66248

Description	Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:0.03 μM (IC50) COX-2:1.2 μM (IC50)
References	[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56.

Density	1.58g/cm3
Boiling Point	523.9ºC at 760mmHg
Melting Point	230° (dec)
Molecular Formula	C₁₄H₉ClN₂O₃S
Molecular Weight	320.75
Flash Point	270.7ºC
Exact Mass	320.00200
PSA	111.87000
LogP	4.01840
Appearance	faint yellow to dark yellow
Vapour Pressure	7.42E-13mmHg at 25°C
Index of Refraction	1.756
Storage condition	Store at +4°C
Water Solubility	DMSO: soluble1mg/mL, clear (warmed)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport