Atorvastatin lactone D5

Modify Date: 2024-01-10 11:15:29

Atorvastatin lactone D5 Structure
Atorvastatin lactone D5 structure
Common Name Atorvastatin lactone D5
CAS Number 1217749-86-4 Molecular Weight 545.655
Density 1.2±0.1 g/cm3 Boiling Point 674.8±55.0 °C at 760 mmHg
Molecular Formula C33H28D5FN2O4 Melting Point N/A
MSDS N/A Flash Point 361.9±31.5 °C

 Use of Atorvastatin lactone D5


Atorvastatin lactone D5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

 Names

Name 5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N-phenyl-4-(2H5)phenyl-1H-pyrrole-3-carboxamide
Synonym More Synonyms

 Atorvastatin lactone D5 Biological Activity

Description Atorvastatin lactone D5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].
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References

[1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 674.8±55.0 °C at 760 mmHg
Molecular Formula C33H28D5FN2O4
Molecular Weight 545.655
Flash Point 361.9±31.5 °C
Exact Mass 545.273804
LogP 4.30
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.617

 Synonyms

5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N-phenyl-4-(2H5)phenyl-1H-pyrrole-3-carboxamide
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N-phenyl-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
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