SK1-IN-1
Modify Date: 2025-08-27 00:32:22
SK1-IN-1 structure
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Common Name | SK1-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1218816-71-7 | Molecular Weight | 398.499 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H30N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SK1-IN-1SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM. |
| Name | SK1-IN-1 |
|---|---|
| Synonym | More Synonyms |
| Description | SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 58 nM (SPHK1)[1] |
| In Vivo | SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H30N4O3 |
| Molecular Weight | 398.499 |
| Exact Mass | 398.231781 |
| LogP | 2.39 |
| Index of Refraction | 1.571 |
| InChIKey | GDJANRNMFHNVOW-DCPHZVHLSA-N |
| SMILES | CC(NC(=O)C1NCCC1O)c1ccc(-c2noc(CCC3CCCC3)n2)cc1 |
| Storage condition | 2-8℃ |
| (3S)-N-[(1S)-1-{4-[5-(2-Cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl}ethyl]-3-hydroxy-L-prolinamide |
| 2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)- |