Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride

Modify Date: 2024-01-31 15:14:01

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride structure	Common Name	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
	CAS Number	2245697-85-0	Molecular Weight	587.02
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₅ClN₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
Synonym	More Synonyms

Description	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO2016105518A1.

Molecular Formula	C₂₅H₃₅ClN₄O₁₀
Molecular Weight	587.02

Hazard Codes	Xi

MFCD31656718

Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride

Use of Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride

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