GSK-J5

Modify Date: 2024-01-12 21:25:25

GSK-J5 structure	Common Name	GSK-J5
	CAS Number	1394854-51-3	Molecular Weight	417.50
	Density	1.2±0.1 g/cm3	Boiling Point	581.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₇N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	305.3±30.1 °C

Use of GSK-J5

GSK-J5 is a potent inhibitor of Schistosome and worm. GSK-J5 increases schistosomula mortality and adult worm motility and mortality, as well as egg oviposition, in a dose- and time-dependent manner[1].

Name	Ethyl N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3- yl)-4-pyrimidinyl]-β-alaninate
Synonym	More Synonyms

Description	GSK-J5 is a potent inhibitor of Schistosome and worm. GSK-J5 increases schistosomula mortality and adult worm motility and mortality, as well as egg oviposition, in a dose- and time-dependent manner[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
References	[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [2]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46. [3]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

References

[1]. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8.

[2]. Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46.

[3]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2

Density	1.2±0.1 g/cm3
Boiling Point	581.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₇N₅O₂
Molecular Weight	417.50
Flash Point	305.3±30.1 °C
Exact Mass	417.216461
PSA	80.24000
LogP	3.75
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.615

β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, ethyl ester

Ethyl N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alaninate

GSK-J5

Use of GSK-J5

Names

GSK-J5 Biological Activity

Chemical & Physical Properties

Synonyms