FUBP1-IN-2

Modify Date: 2024-01-11 19:00:45

FUBP1-IN-2 structure	Common Name	FUBP1-IN-2
	CAS Number	1242862-71-0	Molecular Weight	479.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₆ClN₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FUBP1-IN-2

FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

Name	FUBP1-IN-2

Description	FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> c-Myc
In Vitro	FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].
References	[1]. Dobrovolskaite A, et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. J Med Chem. 2022 Nov 24;65(22):15391-15415.

Molecular Formula	C₂₆H₂₆ClN₃O₄
Molecular Weight	479.96

FUBP1-IN-2

Use of FUBP1-IN-2

Names

FUBP1-IN-2 Biological Activity

Chemical & Physical Properties